Article of interest: Diagnostic accuracy of the urinalysis for urinary tract infection in infants <3 months of age.

Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL. Diagnostic accuracy
of the urinalysis for urinary tract infection in infants < 3 months of age. Pediatrics. 2015 May 25. [Epub ahead of print]

This study sheds new light on the diagnostic characteristics of the UA in young infants. A definition of a positive UA that includes pyuria and/or positive LE was highly sensitive and specific. All but 1 of 203 infants with bacteremic UTI and recorded UA results for both LE and WBC/HPF were positive for 1 or both of these tests, and the one infant with negative results for these components was infected with an organism (GBS) not commonly described as a uropathogen. A negative LE and the absence of pyuria were also fairly specific (87.8%) in infants with negative urine cultures. UA bacteria, however, demonstrated poor specificity, suggesting that this component of the UA is not as useful as LE or pyuria for ruling in a UTI.

Full-text for Children’s and Emory users.