Article of interest: Hormonal Contraception and Breast Cancer Risk.

Hormonal Contraception and Breast Cancer Risk.
AAP Grand Rounds Mar 2018, 39 (3) 28.

Full-text for Children’s users.

“While a statistically significant increased risk of breast cancer sounds alarming, it is important to mention some nuances of the relationship between HC and breast cancer. First, though the data are presented as RRs, the absolute increase in risk is only one additional breast cancer case per 50,000 females under the age of 35. Second, the results are not causal proof between HC and breast cancer, and the investigators were unable to control or account for known (eg, alcohol use, physical activity) or unknown contributors to breast cancer risk. Finally, HC has also been shown to substantially protect against other cancers (eg, ovarian, endometrial, and colorectal cancers), with a potential overall reduced risk of total risk of cancer.” [1,3,4]

Commentary on: Mørch LS, et al. Contemporary Hormonal Contraception and the Risk of Breast Cancer. N Engl J Med. 2017 Dec 7;377(23):2228-2239.

Top articles in pediatric medicine (2015-2016)

David Lloyd MD




As chosen by David Lloyd, MD

Petersen LR, et al. Zika Virus. N Engl J Med. 2016 Apr 21;374(16):1552-63.

“In 1947, a study of yellow fever yielded the first isolation of a new virus, from the blood of a sentinel rhesus macaque that had been placed in the Zika Forest of Uganda. [1] Zika virus remained in relative obscurity for nearly 70 years; then, within the span of just 1 year, Zika virus was introduced into Brazil from the Pacific Islands and spread rapidly throughout the Americas. [2] It became the first major infectious disease linked to human birth defects to be discovered in more than half a century and created such global alarm that the World Health Organization (WHO) would declare a Public Health Emergency of International Concern. [3] This review describes the current understanding of the epidemiology, transmission, clinical characteristics, and diagnosis of Zika virus infection, as well as the future outlook with regard to this disease.”

Doan S, Maehara CK, Chaparro JD, Lu S, Liu R, Graham A, Berry E, Hsu N, Kanegaye JT, Lloyd DD, Ohno-Machado L, Burns JC, Tremoulet AH; Pediatric Emergency Medicine Kawasaki Disease Research Group. Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes. Acad Emerg Med. 2016 May;23(5):628-36.

KD-NLP showed comparable performance to clinician manual chart review for identification of pediatric ED patients with a high suspicion for KD. This tool could be incorporated into the ED electronic health record system to alert providers to consider the diagnosis of KD. KD-NLP could serve as a model for decision support for other conditions in the ED.

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Planned home births – policy statements, committee opinions (AAP, ACNM, ACOG) and editorials

ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 476: Planned home birth. Obstet Gynecol. 2011 Feb;117(2 Pt 1):425-8. Erratum in: Obstet Gynecol. 2011 May;117(5):1232.

American College of Nurse Midwives Clinical Bulletin. Criteria for provision of home birth services. 2003. J Midwifery Womens Health. 2003 Jul-Aug;48(4):299-301.

Chervenak FA, McCullough LB, Grünebaum A, Arabin B, Levene MI, Brent RL. Planned home birth: a violation of the best interests of the child standard? Pediatrics. 2013 Nov;132(5):921-3.

Chervenak FA, McCullough LB, Brent RL, Levene MI, Arabin B. Planned home birth: the professional responsibility response. Am J Obstet Gynecol. 2013 Jan;208(1):31-8.

Dixon L. Planned home birth: the professional responsibility response–a midwifery response. Am J Obstet Gynecol. 2013 Sep;209(3):280-1.

MacDorman MF, Mathews TJ, Declercq E. Home births in the United States, 1990-2009. NCHS Data Brief. 2012 Jan;(84):1-8.

Olsen O, Clausen JA. Planned hospital birth versus planned home birth. Cochrane Database Syst Rev. 2012 Sep 12;9:CD000352.

Watterberg KL; Committee on Fetus and Newborn. Policy statement on planned home birth: upholding the best interests of children and families. Pediatrics. 2013 Nov;132(5):924-6.

Wax JR, Pinette MG, Cartin A. Home versus hospital birth–process and outcome. Obstet Gynecol Surv. 2010 Feb;65(2):132-40.

Top articles in pediatric hospital medicine (2012-2013)

How do attendings perceive housestaff autonomy? Attending experience, hospitalists, and trends over time. Martin SK, Farnan JM, Mayo A, Vekhter B, Meltzer DO, Arora VM. J Hosp Med. 2013 Jun;8(6):292-7. doi: 10.1002/jhm.2016. Epub 2013 Feb 15.

Influence of “GERD” label on parents’ decision to medicate infants. Scherer LD, Zikmund-Fisher BJ, Fagerlin A, Tarini BA. Pediatrics. 2013 May;131(5):839-45. doi: 10.1542/peds.2012-3070. Epub 2013 Apr 1. 

Increased length of stay and costs associated with weekend admissions for failure to thrive. Thompson RT, Bennett WE Jr, Finnell SM, Downs SM, Carroll AE.  Pediatrics. 2013 Mar;131(3):e805-10. doi: 10.1542/peds.2012-2015. Epub 2013 Feb 25.

Comparative effectiveness of empiric β-lactam monotherapy and β-lactam-macrolide combination therapy in children hospitalized with community-acquired pneumonia. Ambroggio L, Taylor JA, Tabb LP, Newschaffer CJ, Evans AA, Shah SS.J Pediatr. 2012 Dec;161(6):1097-103. doi: 10.1016/j.jpeds.2012.06.067. Epub 2012 Aug 15.

The long-term outcomes of pediatric pleural empyema: a prospective study. Cohen E, Mahant S, Dell SD, Traubici J, Ragone A, Wadhwa A, Connolly B, Weinstein M. Arch Pediatr Adolesc Med. 2012 Nov;166(11):999-1004. doi: 10.1001/archpediatrics.2012.1055.

The diagnosis and management of empyema in children: a comprehensive review from the APSA Outcomes and Clinical Trials Committee. Islam S, Calkins CM, Goldin AB, Chen C, Downard CD, Huang EY, Cassidy L, Saito J, Blakely ML, Rangel SJ, Arca MJ, Abdullah F, St Peter SD; APSA Outcomes and Clinical Trials Committee, 2011-2012. J Pediatr Surg. 2012 Nov;47(11):2101-10. doi: 10.1016/j.jpedsurg.2012.07.047. Review.

Effects of increased overnight supervision on resident education, decision-making, and autonomy. Haber LA, Lau CY, Sharpe BA, Arora VM, Farnan JM, Ranji SR. J Hosp Med. 2012 Oct;7(8):606-10. doi: 10.1002/jhm.1959. Epub 2012 Aug 3.

Variability in processes of care and outcomes among children hospitalized with community-acquired pneumonia. Brogan TV, Hall M, Williams DJ, Neuman MI, Grijalva CG, Farris RW, Shah SS. Pediatr Infect Dis J. 2012 Oct;31(10):1036-41. Free PMC Article

Clinicians’ gut feeling about serious infections in children: observational study. Van den Bruel A, Thompson M, Buntinx F, Mant D. BMJ. 2012 Sep 25;345:e6144. Free PMC Article

Effect of inhaled glucocorticoids in childhood on adult height. Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, Raissy HH, Van Natta ML, Tonascia J, Strunk RC; CAMP Research Group. N Engl J Med. 2012 Sep 6;367(10):904-12. Epub 2012 Sep 3. Free PMC Article

Quality improvement initiative to reduce serious safety events and improve patient safety culture. Muething SE, Goudie A, Schoettker PJ, Donnelly LF, Goodfriend MA, Bracke TM, Brady PW, Wheeler DS, Anderson JM, Kotagal UR. Pediatrics. 2012 Aug;130(2):e423-31.  Epub 2012 Jul 16. Free PMC Article

Dose-response relationship of phototherapy for hyperbilirubinemia. Vandborg PK, Hansen BM, Greisen G, Ebbesen F. Pediatrics. 2012 Aug;130(2):e352-7. Epub 2012 Jul 16. Free Article

A clinical decision rule to identify infants with apparent life-threatening event who can be safely discharged from the emergency department. Mittal MK, Sun G, Baren JM. Pediatr Emerg Care. 2012 Jul;28(7):599-605. 

Costs and infant outcomes after implementation of a care process model for febrile infants. Byington CL, Reynolds CC, Korgenski K, Sheng X, Valentine KJ, Nelson RE, Daly JA, Osguthorpe RJ, James B, Savitz L, Pavia AT, Clark EB. Pediatrics. 2012 Jul;130(1):e16-24. Epub 2012 Jun 25. Free Article

From Hospital Pediatrics (currently not indexed in PubMed):

Hospitalist and nonhospitalist adherence to evidence-based quality metrics for bronchiolitis.

The best relevant articles in pediatric hospital medicine.

Top articles in pediatric hospital medicine.

The prevalence of bacteremia in pediatric patients with community-acquired pneumonia: guidelines to reduce the frequency of obtaining blood cultures.

Blood culture associations in children with a diagnosis of cellulitis in the era of methicillin-resistant staphylococcus aureus.

Time to detection of bacterial cultures in infants aged 0 to 90 days.

Resident perceptions of autonomy in a complex tertiary care environment improve when supervised by hospitalists.

Are there risks associated with empiric acid suppression treatment of infants and children suspected of having gastroesophageal reflux disease?