Presented by Jenny Lin MD (PGY1)
What is the utility of ordering a Biofire FilmArray GI PCR Panel for a case of acute gastroenteritis?
Biofire FilmArray GI PCR Panel:
- Rapid multiplex PCR panel
- 23 GI pathogens (bacteria, viruses, and protozoa)
- 1 hour
- $129 per test
How Useful is It?
*more than six unformed stools daily, fever, volume depletion requiring hospitalization, immunocompromised, >1 week, or blood, pus, or mucus in the stool
- The BioFire FilmArray GI PCR panel is extremely sensitive and specific, more than traditional testing.
- Viral pathogens dominate in younger children < 5 years, in winter months, and with vomiting.
- Bacterial pathogens are more likely in older children, summer months, and with diarrhea.
- A bacterial etiology is more likely with multiple severe clinical factors.
- If concerned for a protozoal etiology or a severe bacterial etiology, antimicrobial therapy or another change in management may be indicated.
Stockmann C, et al. Detection of 23 Gastrointestinal Pathogens Among Children Who Present With Diarrhea. J Pediatric Infect Dis Soc. 2016 May 4. pii: piw020. [Epub ahead of print]
Buss SN, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015 Mar;53(3):915-25.
Shim DH, Kim DY, Cho KY. Diagnostic value of the Vesikari Scoring System for predicting the viral or bacterial pathogens in pediatric gastroenteritis. Korean J Pediatr. 2016 Mar;59(3):126-31.