Ovarian tumors in children

Zhang M, Jiang W, Li G, Xu C. Ovarian masses in children and adolescents – an
analysis of 521 clinical cases. J Pediatr Adolesc Gynecol. 2014 Jun;27(3):e73-7.

“Germ cell tumors are the most common malignancy, and mature teratomas are the most common benign neoplasms in children and adolescents. Abdominal pain and menstrual disorder are the main reasons for doctor’s visit. Although examination by ultrasound is the preferred auxiliary in the diagnosis of ovarian pathology, it could not distinguish between benign and malignant tumors. However, tumor size and tumor markers are helpful to identify the properties of masses. Surgery is usually better for treatment, and it is preferable to attempt conservative, fertility-sparing surgery in adolescents. Postoperative chemotherapy is necessary for malignant tumors.”

Full-text for Children’s and Emory users.

Amies Oelschlager AM, Sawin R. Teratomas and ovarian lesions in children. Surg Clin North Am. 2012 Jun;92(3):599-613, viii.

“Ovarian pathology in children is common and the pathology can be quite diverse. The most common benign ovarian tumor in childhood is a teratoma. In this article, we discuss the origin of these germ cell tumors followed by a complete discussion of ovarian pathology.”

Full-text access for Children’s and Emory users.

Hatzipantelis ES, Dinas K. Ovarian tumours in childhood and adolescence. Eur J
Gynaecol Oncol. 2010;31(6):616-20.

“Malignant ovarian tumors are very rare during childhood and adolescence where their incidence is approximately 0.71 per 100,000. We reviewed the symptoms, histologic subtypes, diagnostic evaluation and management of ovarian tumours in children and adolescents with emphasis on malignant tumours. The histology of these tumours is complex and their diagnosis frequently poses problems. Surgery and chemotherapy yield high cure rates in patients with malignant germ cell tumours whereas prognosis is poorer in ovarian carcinomas. Elucidation of the mechanisms underlying the pathogenesis of ovarian tumors might further improve the management of these patients.”

Children’s and Emory users, contact Emily Lawson for article.

chultz KA, Sencer SF, Messinger Y, Neglia JP, Steiner ME. Pediatric ovarian tumors: a review of 67 cases. Pediatr Blood Cancer. 2005 Feb;44(2):167-73.

“Fifty-five percent of the 67 ovarian tumors presenting to our centers were malignant. Pain was the most common symptom, although presence of an abdominal mass was frequent, and other symptoms non-specific. Almost all neoplasms presented as unilateral masses and rarely were metastatic at diagnosis. Ovarian tumors must be considered in the differential diagnosis of young girls with abdominal pain, mass, or other non-specific symptoms.”

Full-text for Emory users.

de Silva KS, Kanumakala S, Grover SR, Chow CW, Warne GL. Ovarian lesions in children and adolescents–an 11-year review. J Pediatr Endocrinol Metab. 2004 Jul;17(7):951-7.

“To describe the spectrum of pediatric ovarian pathology, identifying the clinical features and ultrasound characteristics that help in decisions about patient management, and to correlate these with ovarian pathology.

Physiological or functional ovarian cysts are the most common ovarian lesions seen in the pediatric age group and malignant neoplasms are rare. A palpable abdominal mass or ovarian lesion >10 cm was significantly associated with the lesion being neoplastic. Lesions <5 cm in post-pubertal girls were significantly more likely to be non-neoplastic. Ultrasonography is useful in localizing ovarian lesions but is not helpful in determining their pathological nature. Endocrine manifestations sometimes occur with either benign or malignant lesions of the ovary.”

Children’s and Emory users, please contact Emily Lawson for article.

More PubMed results on ovarian tumors.

Created 11/18/12, updated 06/05/14.

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