Presented by Bhavya Doshi, MD
Resident, Department of Pediatrics
- Use of honey-sweetened or honey pacifiers has been shown to cause botulism
- Approximately 10% of honey samples are contaminated with Clostridium botulinum
- 15% of all infant botulism is linked to honey ingestion in the US
- The most heralding signs for infant botulism are a history of constipation, poor feeding and hypotonia
- If strongly suspected, botulism immune globulin should be given within 3 days of admission but has been shown to have benefit up to 7 days after admission
- We need to provide better anticipatory guidance, especially to immigrant parents, about the use of honey in infants
Arnon SS, Schechter R, Maslanka SE, Jewell NP, Hatheway CL. Human botulism immune globulin for the treatment of infant botulism. N Engl J Med. 2006 Feb 2;354(5):462-71.
Benjamins LJ, Gourishankar A, Yataco-Marquez V, Cardona EH, de Ybarrondo L. Honey pacifier use among an indigent pediatric population. Pediatrics. 2013 Jun;131(6):e1838-41. doi: 10.1542/peds.2012-3835. Epub 2013 May 6.
Brook I. Infant botulism. J Perinatol. 2007 Mar;27(3):175-80. Review.
Midura TF, Snowden S, Wood RM, Arnon SS. Isolation of Clostridium botulinum from Honey. J Clin Microbiol. 1979 Feb;9(2):282-3.
Muensterer OJ. Infant botulism. Pediatr Rev. 2000 Dec;21(12):427. Review.
Schreiner MS, Field E, Ruddy R. Infant botulism: a review of 12 years’ experience at the Children’s Hospital of Philadelphia. Pediatrics. 1991 Feb;87(2):159-65.