Emerging drugs for bronchiectasis. (2012)

“In this review, current knowledge of the clinical features, pathophysiology and epidemiology of bronchiectasis among both adults and children is summarized. We discuss the quality and extent of evidence supporting current treatment strategies, focusing on therapies for which the strongest evidence of efficacy exists. We then identify key goals for future research on the causes and treatments of a variety of types of bronchiectasis.”

Children’s and Emory users, please request article from Emily Lawson.

Index of Suspicion. Bronchiectasis. (2011)

“Diagnosis relies predominantly on imaging. Laboratory studies, such as CBC, quantitative immunoglobulins, and sputum culture, may help determine the cause but are nondiagnostic alone. Chest radiograph may reveal airway dilation, increased pulmonary markings with tram tracking (thickening of the bronchial walls), and areas of atelectasis. HRCT is the gold standard for diagnosis and reveals detailed anatomy of the bronchial tree: lack of airway tapering with luminal dilation, bronchial wall thickening, honeycombing, and mucus plugging.”

Full-text access for Children’s users.

A review of non-cystic fibrosis pediatric bronchiectasis. (2008)

“With the implementation of vaccination programs and the use of antibiotics, developed countries have seen a decline in infection-related pediatric bronchiectasis. However, significant morbidity from bronchiectasis is still seen and both infectious and noninfectious causes of bronchiectasis in the pediatric population remain. A review of the literature will be presented including causes of pediatric bronchiectasis, clinical symptoms and signs, laboratory evaluation and imaging, as well as treatment options. This review stresses the importance of early evaluation and treatment in children with recurrent cough, sinusitis, potential foreign-body aspiration, or gastroesophageal reflux to prevent the complications of ongoing respiratory disease and bronchiectasis.”

Full-text access for Emory users.

Tree-in-bud pattern at thin-section CT of the lungs: radiologic-pathologic overview. (2005)

“The tree-in-bud pattern is commonly seen at thin-section computed tomography (CT) of the lungs. It consists of small centrilobular nodules of soft-tissue attenuation connected to multiple branching linear structures of similar caliber that originate from a single stalk. Originally reported in cases of endobronchial spread of Mycobacterium tuberculosis, this pattern is now recognized as a CT manifestation of many diverse entities. These entities include peripheral airway diseases such as infection (bacterial, fungal, viral, or parasitic), congenital disorders, idiopathic disorders (obliterative bronchiolitis, panbronchiolitis), aspiration or inhalation of foreign substances, immunologic disorders, and connective tissue disorders and peripheral pulmonary vascular diseases such as neoplastic pulmonary emboli. Knowledge of the many causes of this pattern can be useful in preventing diagnostic errors. In addition, although the causes of this pattern are frequently indistinguishable at radiologic evaluation, the presence of additional radiologic findings, along with the history and clinical presentation, can often be useful in suggesting the appropriate diagnosis.”

Free full-text access.

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